THC, the psychoactive ingredient in cannabis, interacts with nearly 400 prescription drugs and CBD (cannabidiol) interacts with more than 540. Other scenarios are less common, but are still possible. For example, THC is known to increase the effect of some medications, such as benzodiazepines. It is well documented that THC can increase the potential of benzodiazepines to cause sedative-like effects, which can be both a benefit and a disadvantage depending on how the combination is used.
While generally considered safe, CBD can cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth and, in rare cases, liver damage. Taking CBD with other medications that have similar side effects may increase the risk of developing unwanted symptoms or toxicity. In other words, taking CBD at the same time as over-the-counter or prescription drugs and substances that cause drowsiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol, can cause increased sleepiness, fatigue, and possibly accidental falls and accidents while driving. You can also experience increased sedation and tiredness when consuming certain herbal supplements, such as kava, melatonin and St.
Taking CBD with stimulants (such as Adderall) may cause a decrease in appetite, while taking it with metformin, a medication for diabetes, or with certain medications for heartburn (such as Prilosec), it may increase the risk of diarrhea. It's one of the main benefits of THC-O for most consumers: you can buy it online and have it delivered straight to your door.